1. General Information

1. Composition: Each 100ml vial contains Levofloxacin 500mg as the active ingredient.
2. Form: Intravenous infusion.
3. Packaging: 100ml vial.

2. Product Introduction

Levodexa 500mg/100ml is a broad-spectrum antibiotic belonging to the fluoroquinolone class. It is formulated for intravenous administration to treat a variety of bacterial infections effectively, particularly when oral therapy is not suitable.

3. Uses

1. Treatment of bacterial infections caused by susceptible organisms, including:
2. Community-acquired pneumonia (CAP)
3. Complicated urinary tract infections (UTIs)
4. Pyelonephritis
5. Skin and soft tissue infections
6. Chronic bacterial prostatitis
7. Acute bacterial sinusitis

4. Benefits

1. Rapid onset of action due to intravenous administration.
2. Effective against a wide range of gram-positive and gram-negative bacteria.
3. Provides targeted treatment for serious infections.

5. Side Effects

1. Common: Nausea, diarrhea, dizziness, headache.
2. Serious: Tendon rupture, QT prolongation, hypersensitivity reactions, peripheral neuropathy.
3. Rare: Clostridioides difficile-associated diarrhea.

6. Indication

Levodexa 500mg/100ml is indicated for the treatment of moderate to severe infections caused by levofloxacin-sensitive organisms in adults.

7. Contraindication

1. Known hypersensitivity to levofloxacin or other quinolones.
2. History of tendon disorders associated with fluoroquinolone use.
3. Patients with epilepsy.
4. Children, adolescents, and pregnant or breastfeeding women.

8. How It Works

Levofloxacin works by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes crucial for DNA replication, transcription, and repair in bacteria. This mechanism results in bacterial cell death.

9. Substitute Medicine in Nepal

1. Inj Levoflox 500mg/100ml
2. Inj Levomac 500mg/100ml
3. Inj Levobact 500mg/100ml