1 General Information

Composition: Misoprostol 200 mcg

Form: Oral tablet

2. Product Introduction

Misoprostol 200 mcg is a synthetic prostaglandin E1 analog used primarily for gastrointestinal and obstetric indications. It is commonly prescribed for the prevention and treatment of gastric ulcers, induction of labor, and medical abortion.

3. Uses

1. Prevention of gastric ulcers in patients using NSAIDs
2. Medical abortion (used with mifepristone)
3. Induction of labor
4. Treatment of postpartum hemorrhage (off-label use)

4. Benefits

1. Protects the stomach lining by reducing gastric acid secretion
2. Facilitates safe medical termination of pregnancy
3. Efficiently manages labor induction under medical supervision
4. Prevents severe complications from postpartum bleeding

5. Side Effects

1. Diarrhea
2. Abdominal pain or cramping
3. Nausea and vomiting
4. Uterine contractions (in obstetric use)
5. Fever and chills (temporary)

6. Indication

1. Prevention of NSAID-induced gastric ulcers
2. Termination of early pregnancy
3. Cervical ripening and labor induction
4. Management of postpartum hemorrhage

7. Contraindications

1. Known hypersensitivity to misoprostol or other prostaglandins
2. Pregnancy (if used for gastric ulcers)
3. Suspected ectopic pregnancy (when used for abortion)

8. How It Works

Misoprostol works by mimicking natural prostaglandins in the body. It reduces gastric acid secretion and enhances mucus production in the stomach, protecting the lining. In obstetric use, it stimulates uterine contractions by binding to prostaglandin receptors in the uterus.

9. Substitute Medicine in Nepal

1. Cytotec 200 mcg (Pfizer)
2. Miso 200 mcg (Zydus)
3. Misotac 200 mcg (Alkem)